Postoperative care and pain management are interconnected. More than half the patients who have had surgery experience a certain amount of pain post surgery. There has been advancement with regard to acute pain control but there is a lot of research being done on acute pain models as, despite improved surgical techniques and advancements in technology inadequately controlled pain is still the prime reason for extended hospital stays and the resultant complications & infections. There has been recognition of the economic as well as the humanitarian importance of pain control as well as pain management has prompted attention from various parts of the world from various professionals.
There is a lot of research done to deal with the issues related to acute pain as well as measures to control it with either the drugs or with the use of non-pharmacological interventions. As, even brief episodes of acute pain can result in long-term neuronal remodeling as well as sensitization ('plasticity'), chronic pain, as well a lot of psychological distress. Hence there is an urgent need to find solutions to the problem of inadequate pain relief and the answer lies in better usage of existing technology until further results are established.
The effect of amitriptyline in mice (acute pain models )
When there is acute or nociceptive pain the motor neuron in the central nervous system (CNS) gets the signal to minimize the perceived pain. The analgesic activity in mice (acute pain models) was observed after being administered amitriptyline. The mice were divided into various groups and were then administered amitriptyline in varying doses. This was done alone as well as with a combination of morphine. The Reaction time in the Hot-Plate tests as well as Tail-Flick tests were observed.
Conclusion
The results showed that there was an antinociceptive effect in these acute pain models with amitriptyline. The results proved that amitriptyline when administered in combination with the drug morphine had shown better analgesic effects than just the morphine alone in Hot-Plate test.
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